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UK sickle cell patients ‘get worse care than sufferers of similar disorders’

People living with sickle cell disease face substandard care as its treatment significantly lags behind advances relating to other genetic disorders such as cystic fibrosis, a report has found.

The study, commissioned by the NHS Race and Health Observatory and carried out by researchers at Imperial College London, analysed various measures of care for sickle cell disease between 2010 and 2024, including clinical trials, approved drugs and reviews of existing studies.

The findings indicated that sickle cell care across the UK does not have parity with other genetic disorders, such as cystic fibrosis, with there being only 0.5 specialist nurses per 100 patients for sickle cell, compared with 2 per 100 for cystic fibrosis.

The report also found that there is 2.5 times more research funding for cystic fibrosis than for sickle cell, meaning the former has more treatment options and breakthrough drugs than the latter.

Evidence of substandard care for people with sickle cell was also found, with 20% of babies with the condition not being seen by a specialist by three months of age, despite the NHS screening programme guidelines that 90% of babies should be seen by this milestone.

Prof Habib Naqvi, the chief executive of the observatory, said sickle cell care “significantly lags behind” that for other rare genetic conditions.

He added: “These inequalities are stark and, despite being a common genetic disorder, sickle cell has endured years of inadequate attention and investment that has resulted in the experiences we then see play out for people living with the condition.

“We do highlight the stark inequalities that exist for people with sickle cell in comparison with other rare conditions, but we also offer evidence-based solutions for meaningful change.”

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Source: The Guardian, 19 June 2025

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UK air pollution killing more than 500 people a week, doctors say

Air pollution in the UK is costing more than £500m a week in ill health, NHS care and productivity losses, with 99% of the population breathing in “toxic air”, doctors have said.

Dirty air is killing more than 500 people a week, with health harm to almost every organ of the body caused by air pollution, even at low concentrations, the Royal College of Physicians (RCP) said.

With an impact on mortality and healthy life expectancy, the effects on individuals, society, the economy and the NHS were huge and the threat air pollution posed to public health was greater than previously understood, a landmark report by the college concluded.

The RCP report also highlighted studies providing new information about the significant health dangers of toxic air, including foetal development and risk of cancer, heart disease, stroke, mental health conditions and dementia.

Air pollution in the UK now kills 30,000 people and costs £27bn a year, according to the research, which also said there was no safe level of air pollutants. The figure could even be significantly higher – up to £50bn – if wider impacts such as dementia were taken into account.

Exposure to air pollution can shorten people’s lives by 1.8 years, “just behind some of the leading causes of death and disease worldwide”, including cancer and smoking, the report added.

The college called for action from the government to tackle the crisis, as it urged ministers to “recognise air pollution as a key public health issue”.

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Source: The Guardian, 9 June 2025

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USA: Judge rules hundreds of NIH grant cuts are ‘void and illegal’

The National Institutes of Health (NIH) must restore hundreds of recently cancelled research grants focused on race, gender and sexual orientation, a federal judge ordered 16 June. 

The federal government announced in February it would terminate NIH grants related to diversity, equity and inclusion. Since then, 2,282 grants worth $3.8 billion have been cut, according to the Association of American Medical Colleges. 

Nearly 1,200 of those grants were tied to hospitals and medical schools, including research focused on HIV/AIDS, mental and behavioural health conditions, cancer, substance use disorders and chronic diseases, according to the AAMC.

On 16 June, U.S. District Court Judge William Young directed the NIH to restore much of these grant funds, ruling the cuts are “void and illegal” and accusing the government of racial discrimination and prejudice against the LGBTQ community. 

A spokesperson for HHS, which oversees the NIH, told The Hill that the agency plans to appeal or halt the ruling. 

The NIH faces significant funding cuts for 2026 as President Donald Trump’s budget proposal, published 2 May, would trim the NIH’s funding from around $48 billion to $27 billion. The proposal is undergoing the congressional appropriations process.

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Source: Becker's Hospital Review, 17 June 2025

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Warning over filler injections in public toilets

Cosmetic procedures such as fillers, Botox and Brazilian butt lifts are taking place in public toilets, hotel rooms and other "shocking locations" in Britain, officials have warned.

People's lives "are being put at risk every single day" by the lack of regulation in the industry, the Chartered Trading Standards Institute (CTSI) says, as it called for urgent action to set up a licensing scheme.

It has also uncovered unsafe fillers and fat-dissolving injections being sold online.

The Department for Health and Social Care says the government is looking into new regulations to protect people.

Kerry Nicol, external affairs manager at the CTSI, said she was "genuinely shocked by the scale of potential harm facing the public due to the alarming lack of regulation in the aesthetic industry".

She added that "action is urgently needed" to crack down on "bad players operating in this sector" and a cross-government approach was required.

The priority is giving the public a clear indication of who is qualified to carry out these procedures, Ms Nicol said.

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Source: BBC News, 18 June 2025

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Nearly 200 patients harmed in major cyber attack

The NHS has confirmed nearly 200 patients were harmed as a result of a major cyber attack last year.

One year on from the ransomware attack that shut down the IT systems used by south east London’s pathology provider Synnovis, managers confirmed nearly 600 incidents, of which 170 involved patient care suffering.

This includes one case of “severe” harm, which has prompted a patient safety incident investigation at King’s College Hospital Foundation Trust, 14 examples that were classed as “moderate”, and another 155 defined as “low harm”.

The attack in June 2024 left GPs across six boroughs unable to order blood tests, and more than 1,000 inpatient procedures were cancelled at two large hospital trusts.

The attack meant the pathology IT systems depended on by two of England’s biggest provider trusts – Guy’s and St Thomas’ and King’s College Hospital foundation trusts – and 192 GP practices were largely inoperable. Large quantities of tests in primary care were deferred or cancelled; and those carried out had to be sent to the pathology networks in north central and south west London.

The hospitals were unable to carry out some procedures involving blood transfusion, including surgery, with many diverted to other providers. Some cancer treatments were also delayed or diverted, as well as some transplants and specialist maternity work.

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Source: HSJ, 18 June 2025

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Bullying and discrimination threaten to shape another NHS restructure

NHS restructures are exposing deep-rooted inequalities, as valued staff face exclusion, intimidation, and unfair treatment under the name of change says Roger Kline and Joy Warmington in an HSJ article.

“The need to do things in a hurry”, we are told, is the system’s way of getting around normal recruitment processes, such as senior appointments in NHS England, trusts and elsewhere – especially the “temporary” ones that become permanent.

Across the NHS, we have heard of a significant number of perfectly competent and high-performing staff (especially senior staff) suddenly finding themselves criticised just ahead of the announcement of a restructure. Suspicious? Extremely, especially ahead of restructures where a favoured candidate is earmarked for the role.

A significant number of these staff are threatened with being performance managed and subjected to investigations whose only purpose seems to be to demoralise and make voluntary redundancy seem attractive. Nepotism is hardly a stranger to senior NHS appointments, but the scale of planned redundancies and restructure appears to have acted to normalise this poor practice.

For example, Alice is a very senior manager with impeccable credentials and appraisals, but finds herself in a restructure in which a close friend of her manager is in direct competition when two jobs become one.

Suddenly, she found herself accused of poor performance and is micromanaged and marginalised. She collapsed at work and is off sick.

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Source: HSJ, 16 June 2025

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Hospitals’ ‘long-term poor culture’ called out by CQC

A major acute trust has been warned by the Care Quality Commission about a “long-term history of poor culture” in one of its departments.

Mid and South Essex Foundation Trust has received a warning notice from the Care Quality Commission over its children and young people’s services, following an inspection last November.

Chief executive Matthew Hopkins told the trust board in June that several concerns were raised by the CQC, including over “actions to improve the long-term history of poor culture and ineffective multidisciplinary team working”.

The CQC told HSJ its inspectors also identified concerns about culture, management and oversight of safety risks and a lack of learning from incidents. It said it carried out the inspection after concerns were identified through its ongoing monitoring.

A Section 29A warning notice means the CQC believes significant improvements in the quality of healthcare are required.

Nicki Abbott, the managing director for women and children, said an action plan was being developed in light of the warning notice. She said: “The issues relating to culture are known and were already being addressed”.

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Source: HSJ, 17 June 2025

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Government warned against 10-Year Plan ‘restructure’

One of the central ideas in the 10-Year Health Plan is “not novel” and could be damaging if it imposes a “one size fits all” model, a community health leader has told HSJ.

Steph Lawrence was, until last year chief nurse at Leeds Community Healthcare Trust, which has been celebrated by Labour leaders for its development of integrated care and out-of-hospital working.

Next month, she becomes chief executive of the Queen’s Institute of Community Nursing, representing staff who will need to be central to a “neighbourhood health service” – a proposal due to feature heavily in the government’s 10-Year Health Plan. 

She spoke to HSJ before taking up the post. Asked about neighbourhood health (NH), she warned: “I don’t think this is a new idea. I don’t think this is anything novel. In Leeds, we have had integrated neighbourhood teams since about 2012 or 2013…

“It’s the right thing to do. But [what] worries me is that every neighbourhood will be different, and therefore one size is never going to fit all…

“Sometimes we get this impression that if we put teams together in one place, they’ll naturally get on and work together. That isn’t how it works. It works by developing relationships and making sure you focus on the person, not what the service needs”.

The nurse leader’s comments come amid fears the plan, expected next month, may encourage a takeover of community and other services by acute providers.

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Source: HSJ, 17 June 2025

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‘Extremely disturbing and unethical’: new rules allow VA doctors to refuse to treat Democrats, unmarried veterans

Doctors at Department of Veterans Affairs (VA) hospitals nationwide could refuse to treat unmarried veterans and Democrats under new hospital guidelines imposed following an executive order by Donald Trump.

The new rules, obtained by the Guardian, also apply to psychologists, dentists and a host of other occupations. They have already gone into effect in at least some VA medical centers.

Medical staff are still required to treat veterans regardless of race, color, religion and sex, and all veterans remain entitled to treatment. But individual workers are now free to decline to care for patients based on personal characteristics not explicitly prohibited by federal law.

Language requiring healthcare professionals to care for veterans regardless of their politics and marital status has been explicitly eliminated.

Doctors and other medical staff can also be barred from working at VA hospitals based on their marital status, political party affiliation or union activity, documents reviewed by the Guardian show. The changes also affect chiropractors, certified nurse practitioners, optometrists, podiatrists, licensed clinical social workers and speech therapists.

In making the changes, VA officials cite the president’s 30 January executive order titled “Defending Women from Gender Ideology Extremism and Restoring Biological Truth to the Federal Government”. The primary purpose of the executive order was to strip most government protections from transgender people. The VA has since ceased providing most gender-affirming care and forbidden a long list of words, including “gender affirming” and “transgender”, from clinical settings.

Medical experts said the implications of rule changes uncovered by the Guardian could be far-reaching.

They “seem to open the door to discrimination on the basis of anything that is not legally protected”, said Dr Kenneth Kizer, the VA’s top healthcare official during the Clinton administration. He said the changes open up the possibility that doctors could refuse to treat veterans based on their “reason for seeking care – including allegations of rape and sexual assault – current or past political party affiliation or political activity, and personal behavior such as alcohol or marijuana use”.

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Source: The Guardian, 16 June 2025

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NHS call handlers quitting over stress amid ‘relentless exposure to trauma’

NHS call handlers are quitting amid burnout at dealing with 999 calls about suicides, stabbings and shootings and the long delays before ambulances reach patients.

The pressure is so intense that 27% of control room staff in ambulance services across Britain have left their jobs over the last three years, NHS figures show.

Many feel overwhelmed by the demands of their roles, unsupported by their employers and powerless to help patients who are facing life-or-death emergencies, according to a report by Unison, with some resigning within a year of starting the role.

Call handlers get so stressed that they took an average of 33 sick days a year each between 2021/22 and 2024/25, data obtained by the union also showed. That is far higher than the average four days taken off sick by workers in the UK overall.

A report by Unison found that call handlers’ jobs have become increasingly challenging in recent years as the demand for care, which rose during Covid, has remained consistently high since, while ambulance handover delays outside hospitals have worsened.

“These findings paint a bleak picture of the conditions faced by 999 control room staff. TV programmes about ambulance services don’t show things as they really are,” said Christina McAnea, the Unison general secretary.

Unison’s report said: “Relentless exposure to traumatic and increasingly complex incidents, verbal abuse, long shifts and low pay are contributing to stress, burnout and fatigue.

One call handler told Unison: “Some shifts are overwhelmingly traumatic, with 90% of the calls of a distressing nature. One shift, I handled three road traffic accidents and two cardiac arrests.”

“There’s a persistent pressure to remain on the phone, no matter how emotionally drained we are.”

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Source: The Guardian, 17 June 2025

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'My baby died after I was ignored' - families call for NHS maternity inquiry

When Tassie Weaver went into labour at full term, she thought she was hours away from holding her first child. But by the time she was giving birth, she knew her son had died.

Doctors had previously told Tassie to call her local maternity unit immediately, she says, as she was considered high risk and needed monitoring, due to high blood pressure and concerns about the baby's growth. But a midwife told her to stay at home.

Three hours later she called again, worried because now she couldn't feel her baby moving. Again, she was told to stay at home, the same midwife saying that this was normal because women can be too distracted by their contractions to feel anything else.

"I was treated as just a kind of hysterical woman in pain who doesn't know what's going on because it's their first pregnancy," the 39-year-old tells us.

When she called a third time, a different midwife told her to come to hospital, but when she arrived it was too late. His heart had stopped beating.

Tassie and her husband John believe Baxter's stillbirth at the Leeds General Infirmary (LGI), four years ago, could have been prevented - and a review by the trust identified care issues "likely to have made a difference to the outcome".

The couple are among 47 new families who have contacted the BBC with concerns about inadequate maternity care at Leeds Teaching Hospitals (LTH) NHS Trust between 2017 and 2024.

As well as the new families, three new whistleblowers - two who still work for the trust - have shared concerns about the standard of care at its two maternity units - at the LGI and St James' University Hospital. This is in addition to the two we spoke to in the initial BBC investigation.

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Source: BBC News, 17 June 2025

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NHS staff unsettled by patients filming care and posting videos on social media

NHS staff have voiced concern about the growing numbers of patients who are filming themselves undergoing medical treatment and uploading it to TikTok and Instagram.

Radiographers, who take X-rays and scans, fear the trend could compromise the privacy of other patients being treated nearby and lead to staff having their work discussed online.

The Society of Radiographers (SoR) has gone public with its unease after a spate of incidents in which patients, or someone with them in the hospital, began filming their care.

On one occasion a radiology department assistant from the south coast was inserting a cannula into a patient who had cancer when their 19-year-old daughter began filming.

“She wanted to record the cannulation because she thought it would be entertaining on social media. But she didn’t ask permission,” the staff member said.

“I spent the weekend afterwards worrying: did I do my job properly? I know I did, but no one’s perfect all the time and this was recorded. I don’t think I slept for the whole weekend.”

They were also concerned that a patient in the next bay was giving consent for a colonoscopy – an invasive diagnostic test – at the same time as the daughter was filming her mother close by. “That could all have been recorded on the film, including names and dates of birth,” they said.

Ashley d’Aquino, a therapeutic radiographer in London, said a colleague had agreed to take photographs for a patient, “but when the patient handed over her phone the member of staff saw that the patient had also been covertly recording her, to publish on her cancer blog.

“As NHS staff we wear name badges, so our names will be visible in any video. It makes people feel very uncomfortable and anxious.”

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Source: The Guardian, 17 June 2025

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Trusts penalised for exaggerating safety standards

Dozens of trusts have been hit with financial penalties after regulators questioned their claims to be compliant with maternity safety standards.

The maternity incentive scheme, run by NHS Resolution, gives trusts “refunds” on their payments to its clinical negligence scheme if they meet 10 safety-related criteria, which trust boards must declare against each year.

The 10 requirements include appropriate staffing, reviewing deaths using a national tool, and board oversight of maternity services.

However, NHS Resolution can investigate if concerns are raised — for example in a Care Quality Commission inspection — and these conflict with the trust’s submission. The payments to trusts can then be withdrawn, or withheld if they have not already been paid.

HSJ analysis of data shared by NHS Resolution found 24 trusts had to make one or more repayments in the first four years of the scheme, which started in 2018 and was relaunched after the pandemic.

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Source: HSJ, 17 June 2025

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‘Milestone’ treatment could reshape future leukaemia care

A UK trial has found that a chemotherapy-free approach to treatment may lead to better outcomes for some leukaemia patients, in what scientists are calling a "milestone".

The groundbreaking UK-wide trial could reshape the way the most common form of leukaemia in adults is treated.

Researchers from Leeds assessed whether two targeted cancer drugs could perform better than standard chemotherapy among patients with chronic lymphocytic leukaemia (CLL).

The Flair trial, which took place at 96 cancer centres across the UK, saw 786 people with previously untreated CLL randomly assigned to receive standard chemotherapy; a single targeted drug, ibrutinib, or two targeted drugs taken together, ibrutinib and venetoclax, with treatment guided by personalised blood tests.

Researchers found that after five years, 94% of patients who received ibrutinib plus venetoclax were alive with no disease progression.

This compares with 79% for those on ibrutinib alone and 58 per cent for those on standard chemotherapy, according to the study, which has been published in the New England Journal of Medicine and presented to the European Haematology Association congress in Milan, Italy.

Dr Talha Munir, consultant haematologist at Leeds Teaching Hospitals NHS Trust, who led the study, said the Flair trial is a “milestone”.

“We have shown that a chemotherapy-free approach can be not only more effective but also more tolerable for patients,” she said.

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Source: The Independent, 16 June 2025

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Senior health figure accuses NHS of racism over care given to dying mother

A senior figure in the health service has criticised it for deep-seated racism after his mother “got a black service, not an NHS service” before she died.

Victor Adebowale, the chair of the NHS Confederation, claimed his mother Grace’s lung cancer went undiagnosed because black people get “disproportionately poor” health service care.

The NHS’s failure to detect her cancer while she was alive shows that patients experience “two different services”, based on the colour of their skin, Adebowale said.

His mother, Grace Amoke Owuren Adebowale, a former NHS nurse, died in January aged 92. He highlighted her care and death during his speech this week at the NHS Confederation’s annual conference as an example of “persistent racial inequalities in NHS services”.

His remarks prompted fresh concern about the stark differences between the care received by those from black and other ethnic minority backgrounds and white people.

“My mum, who worked for many years as a nurse, died earlier this year at the age of 92. It was difficult. It was not the dignified death that we would have wanted for her,” Adebowale told an audience of NHS bosses.

“It wasn’t the death she deserved. So it makes me clear about the need to address the inequity. I think she got a black service, not an NHS service.”

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Source: The Guardian, 14 June 2025

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Ministers plan to use NHS app to expand clinical trials as part of UK-wide drive

The government is aiming for a significant expansion of clinical trials in the UK, and plans to use the NHS app to encourage millions of people in England to take part in the search for new treatments.

Patients will eventually be automatically matched with studies based on their health data and interests, via the app. The plans envisage alerting them to the trials using smartphone notifications.

NHS trusts that fail to meet targets on trials will also be publicly named, and the best performers will be prioritised for funding, as part of improvements designed to restore Britain’s global reputation for medical research.

The strategy is one of the first to emerge from the government’s forthcoming 10-year health plan for England. It aims to take advantage of changes simplifying NHS records by quickly identifying people suitable for a trial. It will also include measures to streamline the paperwork required for the studies.

It is hoped the reforms will speed up the trials process and attract more pharmaceutical companies to host them in Britain, as ministers in all departments are ordered to find pro-growth measures.

The 10-year health plan will promise to slash set-up times for trials. While it takes about 100 days to set up a trial in Spain, it now takes 250 days in the NHS. The plan will push for commercial clinical trial set-up times to fall to a maximum of 150 days by March 2026.

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Source: The Guardian, 16 June 2025

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RFK Jr. names new slate of vaccine advisers after purging CDC panel

Health Secretary Robert F. Kennedy Jr. has unveiled eight people he has chosen to serve on the Centers for Disease Control and Prevention's vaccine advisory panel – just two days after taking the unprecedented step of removing all 17 sitting members.

On Wednesday, Kennedy listed the names and short bios of the new advisers who will join the Advisory Committee on Immunization Practices, or ACIP, at its upcoming meeting in late June.

"All of these individuals are committed to evidence-based medicine, gold-standard science, and common sense," Kennedy said in a post on X, "They have each committed to demanding definitive safety and efficacy data before making any new vaccine recommendations."

The new members are Dr. Joseph R. Hibbeln, Martin Kulldorff, Retsef Levi, Dr. Robert Malone, Dr. Cody Meissner, Dr. Michael A. Ross, Dr. James Pagano and Vicky Pebsworth.

"This is a huge win for the medical freedom [m]ovement," David Mansdoerfer, former deputy assistant secretary for the Department of Health and Human Services in the first Trump administration, wrote in a post on X, "they did everything by the book to put together this excellent slate of appointees."

Public health advocates are wary.

"Kennedy did not pick people with strong, current expertise in vaccines," says Dorit Reiss, a professor at UC Law, San Francisco, who studies vaccine policy. "It tells me that Kennedy is setting up a committee that would be skeptical of vaccines, and possibly willing to implement an anti-vaccine agenda."

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Source: NPR, 11 June 2025

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Hospital backlog drops to lowest level in two years

The backlog in routine hospital treatments in England has reached its lowest level for two years.

Data for the end of April showed the waiting list dropped to 7.39 million, down from 7.42 million in March.

But it is nine years since the NHS has met its target of 92% of patients being seen in 18 weeks – currently it is just below 60%.

The government has made meeting the target one of its key missions for this parliament – and on Wednesday announced above-inflation rises for the NHS in the coming years to help achieve it.

Responding to the latest figures, Health and Social Care Secretary Wes Streeting, said: "We are putting the NHS on the road to recovery."

And he added this was "just the start" as the extra investment announced in the spending review, which will see the NHS budget rise by 3% a year in the next three years, combined with reforms that will be announced in the 10-year plan due next month, would help build on what has been achieved.

The drop in the numbers on the waiting list, which covers people waiting for routine treatments like hip and knee operations, came after March saw a rise in numbers – the first time in six months the waiting list had gone up.

Although a little bit of fluctuation from month to month is normally seen, the government said it was clear the numbers waiting were on a downward trend.

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Source: BBC News, 12 June 2025

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Sickle cell patients to have quicker and more accessible treatment in England

People living with sickle cell disease in England are to benefit from quicker and more accessible treatment due to a £9m investment, the government has announced.

Apheresis services, which are a type of treatment that removes harmful components from a patient’s blood, are to improve across England through the funding of more specialist treatment centres. The funding will ensure the wider availability of machines that remove a patient’s sickled red blood cells and replace them with healthy donor cells.

More than 20 NHS trusts currently offer Spectra Optia technology, a treatment more effective than blood transfusions and having been shown to be highly effective in reducing complications such as iron overload.

The investment could save the NHS up to £12.9m every year thanks to a reduction in time spent in hospital for patients and the reduced need for other treatments, according to the government.

Wes Streeting, the health and social care secretary, said: “People living with rare conditions like sickle cell disease face immense everyday challenges, and can sometimes struggle to get the specialised care they need.

“To make our health service fit for the future, we have to harness the power of new technologies, and these machines provide a shining example of how our government is starting to make huge advancements in digital healthcare.

“Through our plan for change, this government will be the one that removes the barriers to getting the latest and best tech to our NHS frontline, so patients can access the best care available, closer to home.”

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Source: The Guardian, 13 June 2025

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‘Virtual hospitals’ to be launched in 10-Year Plan

The upcoming 10-Year Health Plan is set to propose the introduction of “virtual hospitals” based on patients directly contacting consultants on an Uber-style platform, HSJ has been told.

Senior sources have indicated the proposal will involve a major overhaul and expansion of the existing “advice and guidance” model, whereby GPs can seek advice from a consultant before referring a patient to hospital, in the hope of finding an alternative.

Described by one well-placed official as “Uber for consultants”, the new proposal would create a system for GPs and individual patients to directly seek advice from any consultants, including those outside their home area, who make themselves available.

It is being described as “virtual hospitals” or “virtual clinics”.

Speaking at a session hosted by HSJ at NHS ConfedExpo this week, NHS England chair Penny Dash described a similar model which she said was “in the foothills” of development and could reap large benefits.

She said there should be a “much easier way” of GPs getting advice “from anywhere in the country” to help divert a patient from secondary care.

Dr Dash said: “It could be, for example, a model whereby you put in your question, let’s initially say as a GP or a practice nurse, it goes into a central repository as it were, and you have a team of [consultants] who are available for that time who are looking at it and responding to it.

“It doesn’t have to be the [consultant] in your local district general hospital, it could be anyone anywhere in the country.”

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Source: HSJ, 13 June 2025

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Blood cancer patients in England first in world to be offered ‘Trojan horse’ drug

Thousands of patients in England with blood cancer will become the first in the world to be offered a pioneering “Trojan horse” drug that sneaks inside cancer cells and wipes them out.

In guidance published on Friday, the National Institute for Health and Care Excellence (Nice) gave the green light to belantamab mafodotin, which can halt the advance of multiple myeloma for three times as long as standard treatments.

The targeted therapy, which is given as an infusion every three weeks with other cancer drugs, is a special type of antibody drug that targets and attaches to cancer cells.

It has been described as a Trojan horse treatment because it works by being taken into a cancer cell and unleashing a high concentration of a lethal molecule to destroy the cell from inside.

Prof Peter Johnson, NHS England’s national clinical director for cancer, said the drug would be life-changing for patients and their families.

“Myeloma is an aggressive type of blood cancer, but we have seen a steady improvement in the outlook for patients over recent years as we have introduced new targeted therapies,” he said.

“I am delighted that patients in England will be the first to benefit from this new treatment, which has the potential to keep cancer at bay for years longer, giving people the chance of more precious time with friends and family.”

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Source: The Guardian, 13 June 2025

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Hay fever sufferers warned against buying Kenalog medication online

Pharmacists are warning the public against buying unlicensed hay fever medication online, including the jab Kenalog, because of safety fears.

The National Pharmacy Association (NPA) said people should not buy Kenalog, which can be advertised on social media sites or by salons and beauty clinics.

The organisation, which represents more than 6,000 independent community pharmacies, said health staff have been receiving more and more enquiries about Kenalog.

It is concerned that medication from unregulated sellers could be fake and poses a risk to patient safety.

The drug also has known side-effects, such as increased blood pressure, dizziness, severe abdominal pain, depression and mood swings.

Kenalog is a prescription-only medicine that is not licensed for the treatment of hay fever in the UK.

It contains triamcinolone acetonide, which is a steroid injection licensed for a number of conditions such as arthritis, but not for hay fever.

In 2022, the regulator the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committees of Advertising Practice (CAP) issued a joint enforcement notice about the advertising of Kenalog injections.

They told all organisations offering Kenalog as a hay fever treatment to stop advertising it on any of their social media or website advertising.

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Source: ITVX, 10 May 2025

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NIH grant cuts have pulled $2B from medical schools, academic hospitals

National Institutes of Health (NIH) grant terminations have pulled almost $2 billion in funding away from U.S. medical schools and hospitals, including $314.5 million in funding intended to train biomedical and health researchers, according to an analysis from the Association of American Medical Colleges (AAMC).

The halted funding undercuts medical schools and academic hospitals’ financial sustainability, immediately ended at least 160 active clinical trials for patients being treated for conditions like HIV/AIDS or cancer and threatens “the ability of academic medicine to attract and retain the best and brightest scientists,” the association warned in a Wednesday data brief.

An accompanying release from the AAMC framed the grant terminations alongside a slew of proposed executive and legislative actions it said threaten academic medicine and millions of patients, such as Medicaid provider tax limits and eliminating federal student aid programmes.

“For generations, bipartisan leaders have recognized that America’s strength and future rely on the groundbreaking research performed at our nation’s biomedical research facilities, the complex and highly sophisticated care provided at academic health systems that is the envy of the world, and the ability of our medical schools and teaching hospitals to train the next generation of physicians," AAMC President and CEO David Skorton, M.D., said in a position piece published Wednesday. “For the sake of medical advancement, economic prosperity, and the health of every citizen, we need policymakers to work with us, not against us. The stakes could not be higher—lives truly hang in the balance.”

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Source: Fierce Healthcare, 11 June 2025

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CQC warns trust over maternity staffing

The trust with the highest perinatal mortality rates in the country has been told it must improve its midwifery staffing.

Leeds Teaching Hospitals Trust is now reporting weekly to the Care Quality Commission about staffing on its maternity wards after being served a section 29A warning notice, it has emerged.

It followed inspections of its maternity and neonatal services in December and January. The trust, one of the largest in England, has already moved some neonatal care out of one of its hospitals, after issues were raised by the inspection.

It was also told to provide details to the CQC about how its board is informed about unmitigated risks and how its quality review meetings are assured over midwifery staffing, according to information seen by HSJ.

The trust also promised to provide assurance shifts would be filled by qualified and competent staff and that its rota would be compliant with numbers dictated by the Birthrate Plus safer staffing tool. The requirements remain in force until the CQC decides they are no longer needed.

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Source: HSJ, 11 June 2025

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