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New vaccine 'could wipe out' ovarian cancer

The world's first vaccine for ovarian cancer, being developed in the UK, could wipe out the disease, researchers have said.

Scientists at the University of Oxford are creating OvarianVax, a vaccine which teaches the immune system to recognise and attack the earliest stages of ovarian cancer.

Cancer Research UK is funding the study with up to £600,000 over the next three years.

Director of the university's ovarian cancer cell laboratory Prof Ahmed Ahmed said they still had "a long way to go" but he was "very optimistic".

There are around 7,500 new ovarian cancer cases every year in the UK.

There is no screening test and it is often diagnosed late because the symptoms - such as bloating and no appetite - can be vague.

Genetic mutations put some women at a higher risk of developing the disease and, currently, women with certain genetic mutations are advised to have their ovaries removed before the age of 35.

Prof Ahmed said, if effective, the vaccine could remove the need for this.

Whilst the "full-blown timeline" for a vaccine being approved "might be many years away", Prof Ahmed said, if the vaccine was successful, it could have an impact within the next five years.

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Source: BBC News, 4 October 2024

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New US Surgeon General Advisory sounds alarm on health worker burnout and resignation

The United States Surgeon General Dr. Vivek Murthy issued a new Surgeon General’s Advisory highlighting the urgent need to address the health worker burnout crisis across the country. Health workers, including physicians, nurses, community and public health workers, nurse aides, among others, have long faced systemic challenges in the health care system even before the COVID-19 pandemic, leading to crisis levels of burnout. The pandemic further exacerbated burnout for health workers, with many risking and sacrificing their own lives in the service of others while responding to a public health crisis. Promoting the mental health and well-being of our nation’s frontline health workers is a priority for the Biden-Harris Administration and a core objective of President Biden’s national mental health strategy, within his Unity Agenda.  

The Surgeon General’s Advisory Addressing Health Worker Burnout lays out recommendations that the whole-of-society can take to address the factors underpinning burnout, improve health worker well-being, and strengthen the nation’s public health infrastructure.   

“At the height of the COVID-19 pandemic, and time and time again since, we’ve turned to our health workers to keep us safe, to comfort us, and to help us heal,” said Secretary of Health and Human Services Xavier Becerra. “We owe all health workers – from doctors to hospital custodial staff – an enormous debt. And as we can clearly see and hear throughout this Surgeon General’s Advisory, they’re telling us what our gratitude needs to look like: real support and systemic change that allows them to continue serving to the best of their abilities. I’m grateful to Surgeon General Murthy for amplifying their voices today. As the Secretary of Health and Human Services, I am working across the department and the U.S. government at-large to use available authorities and resources to provide direct help to alleviate this crisis.”

“The nation’s health depends on the well-being of our health workforce. Confronting the long-standing drivers of burnout among our health workers must be a top national priority,” said Surgeon General Vivek Murthy. “COVID-19 has been a uniquely traumatic experience for the health workforce and for their families, pushing them past their breaking point. Now, we owe them a debt of gratitude and action. And if we fail to act, we will place our nation’s health at risk. This Surgeon General’s Advisory outlines how we can all help heal those who have sacrificed so much to help us heal.”   

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Source: HHS, 23 May 2022

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New trust’s ‘inexperienced’ leadership criticised as CQC serves warning

The Care Quality Commission (CQC) has criticised a new trust’s leadership after issuing it with a warning notice to improve care in its two emergency departments.

The watchdog warned North Cumbria Integrated Care Foundation Trust that patients were not always receiving timely and appropriate care, while delayed transfers of care had “resulted in significant delays in admitting patients on to wards”.

The CQC — which carried out focused inspections at the trust in August and September after concerns were raised about risks to patient and staff safety — added there was evidence of “insufficient numbers of suitably qualified, skilled, competent and experienced clinical staff”.

The CQC also said there was a lack of an effective system to mitigate risks, including infection control in the emergency department escalation areas and on some medical wards.

Of the trust’s Cumberland Infirmary and West Cumberland hospitals, the CQC said: “People could not access the urgent and emergency care and medicine service when they needed them and often had long waits for treatment.”

The CQC’s inspection report, published today, also said the trust had an “inexperienced leadership team” which “did not always have the necessary skills and abilities to lead effectively”. It added there were “few examples of leaders making a demonstrable impact on the quality or sustainability of services”.

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Source: HSJ, 30 November 2020

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New trial to speed up breast cancer screening for 700,000 women

Health secretary Wes Streeting has announced a landmark trial that will harness artificial intelligence to help catch breast cancer cases earlier, potentially helping the tens of thousands of women diagnosed with the disease each year.

Nearly 700,000 women through 30 testing sites around the country will take part in the trial, which will use AI to assist radiologists in mammogram screening to identify changes in breast tissue which could be a possible sign of breast cancer.

At the moment mammograms require the expertise of two radiologists, but the Department of Health and Social Care said the AI technology will mean only one specialist will be needed to conduct the screening process safely and efficiently.

If successful the trial could free up radiologists and other specialists to conduct more testing which could help reduce waiting lists.

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Source: The Independent, 4 February 2025

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New triage policy implicated in 44-year-old’s death

An ambulance service says it has sped up clinical review of lower-priority calls, after a coroner said the new triage process — introduced in response to recent waiting time pressures — ‘will lead to further deaths’.

The coroner raised concerns with West Midlands Ambulance Service after a type 1 diabetic patient died following a long delay in deciding whether to send an ambulance.

Following a pilot in July 2021, all category 3 and 4 incidents at WMAS, except for a predefined list of exceptions, are sent directly to the trust’s “clinical validation team” to triage patients, with the aim of reducing the need for ambulance call-outs. It is thought a similar approach has been introduced across England since covid, as there have been huge pressures on ambulance capacity.

But coroner Emma Serrano has raised concerns about the process in a prevention of future deaths report published this week.

The inquest was told that Ms Finch waited 10 hours for her call to be “clinically assessed” and an ambulance call-out approved as the validation team was “under-staffed”. The PFD report also said that there was “no time limit” for assessments to take place, and no prioritisation system.

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Source: HSJ, 14 June 2023

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New treatment ‘can help people stop taking opioid painkillers for chronic pain’

A new treatment could help people to stop taking addictive opioid painkillers for chronic pain, research suggests.

Data suggests there are one million people at risk from longer-term continuous opioid prescriptions, and more than 50,000 have been taking these for six months or more.

While recent NHS initiatives have managed to reduce opioid prescribing by 8%, saving an estimated 350 lives, the new research has found evidence that could help many more people stop their opioid painkiller use.

A team of researchers and doctors has developed and successfully trialled a programme designed to guide people in coming off prescription painkillers, tapering their opioid intake and learning how to manage their pain using alternative techniques with a course which combines one-to-one and group support.

According to the findings, after one year, one in five people were able to stop taking opioids without their pain increasing.

The scientists suggest the new treatment is an alternative to opioid use and has potential to give patients a better quality of life.

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Source: The Independent, 23 May 2023

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New training for NHS maternity staff to boost babies safety

Hundreds of senior midwives are to be given new training to help improve culture and leadership across 126 NHS trusts.

Patient safety minister Nadine Dorries said a new £500,000 maternity leadership programme would be rolled out later this year aimed at giving senior staff running maternity wards the skills and knowledge they need to boost culture and safety.

Its one step towards improving the working relationships between midwives and obstetricians and follows the damning report by the Ockenden inquiry into decades of poor care at Shrewsbury and Telford Hospitals Trust.

The report, published last month, highlighted leadership on maternity wards as a key factor in cases at the trust which led to preventable baby deaths and cases of neglect over many years.

Announcing the fund, Nadine Dorries said: “The shocking and tragic findings of the Ockenden Review highlighted the importance of strengthening maternity leadership and oversight as well as fostering more collaborative approaches within maternity and neonatal services.

“I’m pleased to announce a new training programme for NHS maternity leaders, which will empower nurses, midwives and obstetricians to get the best out of their teams, and deliver safe, world-class care to mothers and their babies.”

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Source: The Independent, 12 January 2021

Government press release

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New tool predicts person’s risk of hospitalisation and death from COVID-19

UK researchers have developed a new risk prediction tool that estimates a person’s chance of hospitalisation and death from COVID-19.

The algorithm, which was constructed using data from more than eight million people across England, uses key factors such as age, ethnicity and body mass index to help identify individuals in the UK at risk of developing severe illness.

It’s hoped that the risk prediction tool, known as QCOVID, will be used to support public health policy throughout the rest of the pandemic, in shaping decisions over shielding, treatment or vaccine prioritisation.

The research, published in The BMJ, was put together by a team of scientists across the UK, and has been praised for the depth and accuracy of its findings.

“This study presents robust risk prediction models that could be used to stratify risk in populations for public health purposes in the event of a ‘second wave’ of the pandemic and support shared management of risk,” the researchers say.

“We anticipate that the algorithms will be updated regularly as understanding of COVID-19 increases, as more data become available, as behaviour in the population changes, or in response to new policy interventions.”

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Source: The Independent, 21 October 2020

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New tool could be used to identify those most at risk from coronavirus

A new risk tool could be used to identify those most at threat from COVID-19, so GPs can give patients tailored advice, health officials have said. 

Scientists at Oxford University are working on a clinical risk prediction model, which aims to give individuals more precise information about the likely impact of the disease on them, instead of a blanket approach. 

Health officials said the plans aimed to allow “very individualised discussions” between patients and their doctors, in the event of future outbreaks, particularly as winter approaches. 

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Source: The Telegraph, 23 June 2020

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New tool could 'help UK doctors spot high-risk Covid patients in seconds'

A risk calculator that takes seconds to produce a score indicating a COVD-19 patient’s risk of death could help clinicians make care decisions soon after patients arrive in hospital, according to a large study conducted by a consortium of researchers across the UK.

As UK COVID-19 cases rise, schools reopen and the weather gets colder, doctors at UK hospitals are expected to see an influx of coronavirus patients.

Patients with COVID-19 behave very differently to patients with other conditions such as flu and bacterial pneumonia, said Dr Antonia Ho of the University of Glasgow, one of the study’s authors, and it is very challenging for doctors managing this unfamiliar disease to accurately identify those who are at high risk of deterioration or who can ride out their illness at home.

“So having a tool that … can help clinicians at the front door to accurately group patients who are coming in with COVID-19 into four distinct risk categories – low, intermediate, high and very high risk – is hugely valuable,” she added. “Having an accompanying low-risk score will provide that doctor with increased confidence that the vast majority of people, patients with that low-risk score, will come to no real harm.”

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Source: The Guardian, 9 September 2020

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New tool can spot those most at risk of developing lung cancer, say researchers

Lives could be saved by a new tool that identifies those most at risk of developing lung cancer, according to researchers.

The CanPredict tool can spot those most at risk of developing the disease over the next decade and put them forward for screening tests earlier, researchers from the University of Oxford and the University of Nottingham said. They created and tested CanPredict using the anonymised health records of more than 19 million adults from across the UK and hope it can save “time, money and, most importantly, lives”.

Lung cancer is the leading cause of cancer deaths worldwide and the second most common form of the disease, but early diagnosis has been shown to improve survival rates.

Professor Julia Hippisley-Cox, senior author and professor of clinical epidemiology and general practice at the Nuffield Department of Primary Care Health Sciences, University of Oxford, said: “We hope that this new validated risk tool will help better prioritise patients for screening and ultimately help spot lung cancer earlier when treatments are more likely to help. We’d like to thank the many thousands of GPs who have shared anonymised data for research without whom this would not have been possible.”

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Source: The Independent, 6 April 2023

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New time critical medication resources for health professionals launched

Three new resources have been launched by the Parkinson’s Excellence Network to support UK healthcare professionals in hospitals to improve the delivery of time critical medication for people with Parkinson’s: 

  • An interactive resource showing which NHS organisations have pledged action on time critical medication. Access the map now.
  • Benchmarking to improve the delivery of time critical medication at South Tyneside and Sunderland NHS Foundation Trust: best practice case study. Read the case study. 
  • Self administration: a patient-centred approach to administering time critical Parkinson’s medication at University Hospitals of Leicester NHS Trust: best practice case study. Find out more about self administration.

You can read more about all of this and more in the latest time critical medication blog.

Access all of the time critical medication resources.

Source: Parkinson's UK, 4 November 2024

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New tests may finally diagnose Long Covid

One of the biggest challenges facing clinicians who treat Long Covid is a lack of consensus when it comes to recognising and diagnosing the condition. But a new study suggests testing for certain biomarkers may identify Long Covid with accuracy approaching 80%. 

Effective diagnostic testing would be a game-changer in the Long Covid fight, for it’s not just the fatigue, brain fog, heart palpitations, and other persistent symptoms that affect patients. Two out of three people with Long Covid also suffer mental health challenges like depression and anxiety. Some patients say their symptoms are not taken seriously by their doctors. And as many as 12% of Long Covid patients are unemployed because of the severity of their illness and their employers may be sceptical of their condition.

Researchers at Cardiff University School of Medicine in Cardiff, Wales, United Kingdom, tracked 166 patients, 79 of whom had been diagnosed with Long Covid and 87 who had not. All participants had recovered from a severe bout of acute Covid-19.

In an analysis of the blood plasma of the study participants, researchers found elevated levels of certain components. Four proteins in particular—Ba, iC3b, C5a, and TCC—predicted the presence of Long Covid with 78.5% accuracy.

"I was gobsmacked by the results. We’re seeing a massive dysregulation in those four biomarkers," says study author Wioleta Zelek, PhD, a research fellow at Cardiff University. "It’s a combination that we showed was predictive of Long Covid.." 

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Source: Medscape, 29 November 2023

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New test holds promise for oral cancer detection


A new non-invasive diagnostic test for oral cancer test developed by researchers at the University of Surrey is said to be over 92% accurate at detecting oral squamous cell carcinoma (OSCC) and more than 80% accurate at identifying pre-cancerous oral epithelial dysplasia (OED), according to a proof-of-concept study. 

The news comes in the wake of a recent report showing that cases of oral cancer in the UK increased by 34% over the last decade and have more than doubled compared with 20 years ago. The State of mouth cancer UK report 2022, released last November by the Oral Health Foundation, showed that there were 8846 new cases of mouth cancer diagnosed in the UK over the previous year, with 3034 deaths from the disease.

The test could pave the way for better oral cancer detection, the researchers said. The samples were collected in dental surgeries and mailed to their laboratory for analysis, which demonstrated that the test could be "used in primary care to identify patients in need of specialist care".

Study co-author Dr Fatima Labeed, senior lecturer in human biology from the University of Surrey, said: "Over 300,000 people are diagnosed with oral cancer worldwide–a disease with an alarming mortality rate of around 50%. This suggests that the scientific community doesn't have the tools available to identify oral cancer early enough, and we hope that PANDORA paves the way for more effective clinical diagnostic tools for this terrible disease."

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Source: Medscape, 5 April 2023

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New technology should be paid for ‘like medicines’, says NICE chief executive

The purchase of approved digital products and services used for diagnosing and treating NHS patients should be reimbursed centrally, the chief executive of the National Institute of Health and Clinical Excellence has told HSJ.

Sam Roberts said this was “the minimum a citizen should expect from a digitised health service” and that she was determined “to get that into the [government’s 10-Year Health] plan”.

She described the different financial arrangements for NICE-approved digital products and services as “outrageous”, and said they should instead be treated “like medicines”.

In a wide-ranging interview with HSJ, the NICE CEO also said:

She wanted NICE to “lead the charge” in determining which digital innovations the NHS should adopt

NICE would issue more guidance on which medicines it had previously recommended should no longer be used

A new approach was needed to deal with the impending wave of expensive “preventive medicines” such as the new wave of weight-loss drugs.

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Source: HSJ, 3 June 2025

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New technology for diabetic pregnant women will reduce risk of miscarriage and stillbirth

Thousands of pregnant women with type 1 diabetes are to be given a special artificial pancreas to reduce the risk of stillbirth and miscarriage.

Mothers-to-be with the condition have higher risks as pregnancy hormones can make it harder for them to regulate their blood glucose levels.

Now, expectant mothers in England will be offered a “game-changing” specialised tool to help them manage their blood glucose levels effectively.

The new tool, also known as a hybrid closed loop system, will be offered to the 2,000 women with type 1 diabetes who fall pregnant each year.

It will be also offered to women who have type 1 diabetes and are planning a pregnancy, NHS England said.

The technology, which is linked to a mobile phone app, delivers the precise insulin dosages a woman requires before and during pregnancy.

Unlike other artificial pancreases, this allows pregnant women to set a glucose target to the lower level required to achieve better outcomes in pregnancy, NHS England said.

It also allows remote monitoring by health workers which means fewer check-ups for mothers-to-be.

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Source: The Independent, 5 September 2025

Related reading on the hub:

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New tech allowing district nurses to digitally monitor wounds

A new app has been piloted in North East London to help district nurses document chronic wound management more efficiently. The tech has been used in community services and stores a catalogue of photographs to accurately document chronic wounds. 

District nurses can use the app on a smartphone – making it lightweight, portable and easy to clean. Using two calibration stickers placed either side of the wound, the app can scan it and capture its size and depth to build a 3D image. Nurses can then fill out further characteristics on the software such as colour, pain level, location and smell to give a full picture of the wound’s development.

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Source: Nursing Times,  12 February 2020

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New target for huge NHS App expansion in general practice

The vast majority of GP practices should allow patients to manage their care through the NHS App in less than a year, according to the primary care recovery plan published by government and NHS England today.  

The plan says patients at more than 90% of practices should be able to use the app to see their records, book appointments and order repeat prescriptions by March 2024. Currently, only around 20% of practices offer this, and data revealed recently by HSJ suggested use of the app is flatlining.

The plan says: “We want the public to have access to health information they can trust, find local services, and use the NHS App where this is their preference to see their medical records, order repeat prescriptions, manage routine appointments with their practice or local hospital and see messages from their practice.

“The NHS App ambitions are already a reality for people registered with around 20% of practices, so this plan focuses on how to increase that to over 90% by March 2024.”

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Source: HSJ, 9 May 2023

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New survey reveals only 45% of patients feel in control of their health

A survey by Patient Safety Movement Foundation (PSMF), a global non-profit has found their respondents did not feel in control of their health. 

The survey focused on how the public view on patient safety and preventable medical harm and their understanding of it. Some highlights of the results include:

  • 53.2% knew what the term 'medical error' meant, with only 37% being able to define it
  • 58% worried about medical errors
  • 45.9% of the public felt in control of what happens to their health

The findings of the survey suggest there is still some way to go in educating the public about medical errors and to bring about more awareness on the issue. 

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Source: Business Wire, 07 July 2021

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New support helps parents cope with ICU trauma

Charlotte Creevy's son Seth was two weeks old when he stopped breathing and was rushed to intensive care at a London hospital.

"What kept going through my mind was, 'Is he going to live or die?'"

Charlotte said Seth had contracted three viruses and needed respiratory support.

Thankfully Seth recovered and returned home after being treated at the paediatric intensive care unit (PICU) at St Mary's Hospital in Paddington for three weeks in October 2022.

Now a "first of its kind" support service by the charity Cosmic is being rolled out at the hospital to help parents like Charlotte cope with the trauma of experiencing their child going into intensive care.

"It was awful. I would cry because it was hard not knowing what would happen to Seth," Charlotte added.

"I was only two weeks postpartum after an emergency C-section, so I was physically not in a good way anyway."

Chief executive of Cosmic, Susannah Forland said "things like the beeping of a fridge can trigger trauma or flashbacks".

She added: "The impact can be long-lasting and far-reaching after the families return home.

"Our service will bridge the gap between hospital and home, providing a vital safety net during one of the most emotionally vulnerable times in a parent's life."

Research at St Mary's Hospital found that early intervention helped reduce symptoms of PTSD and other long-term mental health issues among parents, following their child's discharge from intensive care.

After a successful pilot, Cosmic is funding and delivering the post-PICU service on a permanent basis.

It involves providing parents with a booklet containing information and coping mechanisms, a follow-up telephone call by trained staff, and ongoing referral for counselling where needed.

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Source: BBC News, 5 August 2025

Further reading on hub:

How a charity in France is supporting intensive care units: An interview with Anne-Sophie Debue

 

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New support for families critical of pregnancy care

A new service in Somerset is being set up to support women who have had adverse outcomes during pregnancy.

Maternity and neonatal independent senior advocates (MNISA) say they will act on behalf of women if they feel their experience when being cared for during pregnancy led to something going wrong.

This can include death, babies being diagnosed with brain injuries or mothers needing critical care. MNISAs can attend meetings or support users through investigations and complaints.

The service will be piloted until next year and while the role is independent from the maternity and neonatal trust provider (Somerset NHS Foundation Trust), it sits within NHS Somerset.

Jane Innes, a qualified lawyer who has worked across the NHS for 30 years, will take up the new role in Somerset.

She said: "There is an acknowledgement that people's voices need to be heard and listened to so systems can act and respond appropriately."

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Source: BBC News, 11 June 2024

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New super registry: all implanted medical devices to be tracked

A ground-breaking, mandatory national medical device outcome registry has been launched to collate detailed information on all procedures involving high-risk (Class III/IIb) devices, including pacemakers, hip joint replacements and breast implants.

Led by NHS England’s Outcomes and Registries programme, and developed in partnership with NEC Software Solutions (NEC), the Medical Device Outcome Registry platform (MDOR) will capture data on over two million medical device procedures and more than 10 million unique devices used on patients each year across the NHS and independent healthcare sector, addressing recommendations from the Cumberlege review and Patterson inquiry.  

Collecting key details of the procedure, the clinicians involved and devices used, the registry will include clinical observational and patient outcome data, providing a single, comprehensive repository to improve patient safety and outcomes.  

Scott Pryde, delivery director for the Outcomes and Registries Programme, NHS England, said: “Millions of people receive high-risk medical devices and implants every year. Whereas most procedures are a complete success, when things go wrong it can result in serious harm for the patients affected. The Medical Device Outcome Registry will be responsive to concerns about the safety and outcomes of patients who receive high-risk medical devices, such as implants, and will use the data to actively detect, predict and prevent patient harm, and improve outcomes for patients".  

“The result will be in a step change in improving patient safety in these procedures, providing clinicians and healthcare teams with secure access to critical information they can use to inform clinical decisions and improve the experience of patients before, during and after their procedures.”  

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Source: Clinical Services Journal, 31 May 2023

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New study says self-test could prevent up to 1,000 cervical cancer cases a year

About a third of women are overdue for their appointment for life-saving cervical cancer screening – due to embarrassment, discomfort or simply not having enough time to attend.

But offering women an at-home self-test could prevent as many as 1,000 cases of cervical cancer every year, a study led by Queen Mary University of London with King’s College London found.

More than 3,000 women are diagnosed with cervical cancer each year in the UK. It has been estimated that the number would be 5,000 higher if it weren’t for cervical screening.

The number of women participating in cervical screening has been falling, and in 2024, only 66% of those eligible for screening were up to date.

In the study, published in the journal EClinicalMedicine, researchers recruited 13 GP practices in West London to find out the benefits of offering women a take-home test.

One group of GP practices made in-person kit offers to women who were at least six months overdue for their cervical screening, the other group did not. For the first group, when women attended their GP practice for any reason, their doctor or nurse was encouraged to offer them a self-sampling kit.

In the study, people who were 15 months overdue for cervical screening were randomised each month. Half received no special communication, a quarter were mailed a self-sampling kit, and a quarter were sent a letter offering a kit.

Of the 449 women opportunistically offered a kit in a GP appointment, 234 (52%) accepted and returned a sample.

However, the uptake of self-sampling after a postal offer was lower: 12% among those sent a kit, and just 5% for women sent a letter offering a kit.

Researchers estimate that if this approach were adopted across the NHS, 1,000 cases of cervical cancer could be prevented.

dings are directly relevant to current efforts to modernise cervical screening in England. Self-sampling gives women greater control over how and when they get screened.

“This study reinforces that many women welcome the option - particularly when it’s offered in person by a trusted healthcare professional. A simple change like this could have a major impact on preventing cervical cancer.”

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Source: The Guardian, 29 July 2025

Further reading on the hub:

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New study develops a 'core outcome set' to make new surgical techniques safer

A new study has been published focusing on surgical innovation and how it could be made safer. 

The research set out to develop a 'core outcome set', an agreed minimum set of outcomes to measure and report for safe surgical techniques in all audits, research, and clinical practice. 

The study, co-led by Dr Kerry Avery, a Senior Lecturer at the University of Bristol and NIHR Bristol Biomedical Research Centre (BRC) has said "It may surprise many people to learn that surgical procedures haven’t traditionally been subject to the kind of regulation we see in other areas of medicine. But to ensure safety and improve efficiency, a core outcome set is an important step".

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Source: University of Bristol, 13 July 2021

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