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Found 52 results
  1. News Article
    The NHS is falling behind in the race to tackle antibiotic-resistant infections, with the service set to miss two key targets. As part of the government’s 2019 five-year-action plan to tackle the growth in antimicrobial resistance (AMR), the NHS was set the target of reducing the number of healthcare-associated bloodstream infections of three gram-negative bacteria by 25% by March this year, and 50% by the end of March 2024. Infections caused by E. coli, pseudomonas aeruginosa and klebsiella can cause urine or wound infection, blood poisoning or pneumonia. The AMR action plan said: “In the UK, the biggest drivers of resistance [include] a rise in the incidence of infections, particularly gram-negatives.” Last week, health and social care secretary Sajd Javid stressed the continuing importance of the issue, stating that antimicrobial resistance is “one of the biggest health threats facing the world”. Analysis by HSJ has shown there has been only a small decline in the numbers of cases involving the three bacteria since monitoring started. The baseline for measuring the reduction was 2016-17, when there were 23,037 healthcare associated infections related to the bacteria. Read full story (paywalled) Source: HSJ, 21 April 2022
  2. News Article
    The UK needs to do more to use diagnostic testing in the fight against antimicrobial resistance (AMR), the chair of a government-commissioned review on AMR told MPs. Lord O’Neill, an economist and former treasury minister, warned in the review’s final report in 2016 that a continued rise in AMR would lead to 10 million people dying each year by 2050 and made ten recommendations, including the need for rapid diagnostics to reduce unnecessary use of antimicrobials. Speaking to a Commons Science and Technology Committee evidence session on 22 June 2022, Lord O’Neill said that while he was pleased with progress on some of the recommendations published in his review in 2016, especially in the reduction of antimicrobials in agriculture, progress on diagnostics was “woeful”. He said it was “alarming to me how we are not embedding state-of-the-art diagnostic technology right in the middle of our health systems”, adding that it could “really make a huge difference about whether an antibiotic is needed or not, and the right kind of antibiotic”. “Our most aggressive recommendation was that we should ban the use of subjective prescriptions in secondary settings, at least in Western countries, until they’ve gone through a state-of-the-art diagnostics,” he continued. “And nobody’s done it; they claim it’s a vicious circle, the technology isn’t there, but we have to give incentives in order to get this embedded because that would make a permanent difference.” Read full story Source: The Pharmaceutical Journal, 24 June 2022
  3. News Article
    The blanket use of antibiotics in farming has led to the emergence of bacteria that are more resistant to the human immune system, scientists have warned. The research suggests that the antimicrobial colistin, which was used for decades as a growth promoter on pig and chicken farms in China, resulted in the emergence of E. coli strains that are more likely to evade our immune system’s first line of defence. Although colistin is now banned as a livestock food additive in China and many other countries, the findings sound an alarm over a new and significant threat posed by the overuse of antibiotic drugs. “This is potentially much more dangerous than resistance to antibiotics,” said Prof Craig MacLean, who led the research at the University of Oxford. “It highlights the danger of indiscriminate use of antimicrobials in agriculture. We’ve accidentally ended up compromising our own immune system to get fatter chickens.” Read full story Source: The Guardian, 25 April 2023
  4. Content Article
    This blog by Robert Otto Valdez, Director of the US Agency for Healthcare Research and Quality (AHRQ), outlines the setbacks to patient safety and the healthcare workforce caused by the Covid-19 pandemic. He highlights areas of concern including workforce burnout and an increase in healthcare associated infections (HAIs) since 2020. The issues faced by the US healthcare system are not felt equally, and Valdez draws attention to a report that demonstrates worsening health inequalities. The blog includes links to evidence-based research and initiatives developed by AHRQ aimed at improving current patient safety priorities. Toolkits to improve antibiotic use. These resources are based on a “Four Moments of Antibiotic Decision Making” model that has shown success in hospitals, long-term care facilities, and ambulatory care practices. Tools to engage patients and families in making healthcare safer. Patients and families are powerful partners in improving quality and safety in hospital settings, during primary care visits, or whenever a diagnosis is made. These resources help ensure that patients’ voices are heard. Surveys on patient safety culture. This family of surveys asks healthcare providers and staff about the extent to which their organisational culture supports patient safety. Each survey is designed to assess patient safety culture in a specific setting. Diagnostic Centers of Excellence. These grants establishing 10 centres of excellence are aimed at developing systems, measures, and new technology solutions to improve diagnostic safety and quality.
  5. Content Article
    This paper has been produced by the Infection Management Coalition, provides an overview of the challenges in infection control and antimicrobial resistance. It offers recommendations for improving infection management in the following areas: Data Diagnostics and treatment End-to-end care Awareness and education.
  6. News Article
    India faces a “pandemic” of superbugs, the country’s top public health experts have warned, as resistance to common antibiotics has jumped by 10% in just one year In the fifth edition of its annual report on antimicrobial resistance (AMR), the Indian Council of Medical Research warned that urgent action is needed to prevent a major health crisis caused by the rampant misuse of antibiotics. “The resistance level is increasing to five to ten per cent every year for broad spectrum antimicrobials, which are highly misused,” said Dr Kamini Walia, who led the ICMR’s report. “Antibiotic resistance has the potential of taking the form of a pandemic in the near future if corrective measures are not taken immediately.” The report warned that only 43% of pneumonia infections in India could be treated with first line antibiotics in 2021 – down from 65% in 2016. “We could absolutely see a pandemic driven by AMR infections in India,” said Ramanan Laxminarayan, director of the One Health Trust, a global public health think tank. “It is certainly within the realms of possibility, it could be next year or over the next two decades. “Bacterial infections were the biggest killers in the early 20th Century and we risk going back to that time where there are no effective antibiotics and infections can spread rapidly,” he added. Read full story (paywalled) Source: The Telegraph, 16 September 2022
  7. Content Article
    This addendum sets out changes to the commitments in Tackling antimicrobial resistance 2019 to 2024: the UK’s 5-year national action plan. The national action plan is in its third year of delivery and these changes aim to make the commitments: more specific, measurable, achievable, realistic and time-bound (SMART) reflect lessons learned from the coronavirus (COVID-19) pandemic reflect progress that has already been made against ambitions to reduce antibiotic prescribing in food-producing animals work towards new sector targets.
  8. Content Article
    World Antimicrobial Awareness Week takes place from the 18-24 November every year. On this page the WHO explains what antimicrobial resistance is and provides several short explanatory videos about how this can be prevented.
  9. Content Article
    This systematic analysis in The Lancet used data covering 471 million individual records from systematic literature reviews, hospital systems, surveillance systems and other sources. The authors, an international research collective called the Antimicrobial Resistance Collaborators, used this data to estimate deaths and disability-adjusted life-years (DALYs) that have come about as a result of bacterial antimicrobial resistance (AMR). They estimated that, in 2019, 1.27 million deaths were directly attributable to AMR, with the three primary infections involved being lower respiratory and thorax infections, bloodstream infections and intra-abdominal infections. Their analysis shows that AMR death rates were highest in some lower- and middle-income countries, making AMR not only a major health problem globally, but a particularly serious problem for some of the poorest countries in the world.
  10. News Article
    Public Health Minister, Seema Kennedy, has confirmed that Professor Dame Sally Davies will take on the role of UK Special Envoy on antimicrobial resistance (AMR) later this year. Dame Sally will be working across all sectors to deliver a ‘One Health’ response to AMR, which includes health, agriculture and the environment. The appointment of Dame Sally follows the government’s 20-year vision and 5-year national action plan published earlier this year, setting out how the UK will contribute to containing and controlling AMR by 2040. Professor Dame Sally Davies said: “AMR is a complex challenge which needs local, national and global action. The UK should be proud of its world-leading work on AMR. We have made tangible progress but it is essential we maintain momentum. I am honoured to have been asked to continue this vital work on behalf of the UK government.” Last year the government committed £32 million funding to accelerate the UK’s work in the global fight against AMR. The awarded funding will support the development of a state-of-the-art, virtual ‘open access’ centre that will link health outcomes and prescribing data. This technology, led by Public Health England (PHE), will gather real-time patient data on resistant infections, helping clinicians to make more targeted choices about when to use antibiotics and cutting unnecessary prescriptions. PHE will use £5 million in funding to develop a fully functional model ward, the first of its kind in the UK, to better understand how hospital facilities can be designed to improve infection control and reduce the transmission of antibiotic-resistant infections. Other successful funds include £4.4 million to Manchester University to test ‘individualised’ approaches to antibiotic prescribing by bringing together patient care and clinical research, and £3.5 million to the University of Liverpool to apply innovative genome sequencing to enable more personalised antibiotic prescribing. Public Health Minister Seema Kennedy said: “Antibiotic resistance poses an enormous risk to our NHS – we are already seeing the harmful effect resistant bugs can have on patient safety in our hospitals. It is vital that we retain the irreplaceable expertise of Professor Dame Sally Davies – an international expert in AMR – and continue to invest in research.”
  11. Community Post

    Better use of data for medication safety in hospitals

    Kenny Fraser

    Kenny Fraser posted a topic in Medicine management

    NHS hospital staff spend countless hours capturing data in electronic prescribing and medicines administration systems. Yet that data remains difficult to access and use to support patient care. This is a tremendous opportunity to improve patient safety, drive efficiencies and save time for frontline staff. I have just published a post about this challenge and Triscribe's solution. I would love to hear any comments or feedback on the topic... How could we use this information better? What are hospitals already doing? Where are the gaps? Thanks
  12. News Article
    Antimicrobial resistance poses a significant threat to humanity, health leaders have warned, as a study reveals it has become a leading cause of death worldwide and is killing about 3,500 people every day. More than 1.2 million – and potentially millions more – died in 2019 as a direct result of antibiotic-resistant bacterial infections, according to the most comprehensive estimate to date of the global impact of antimicrobial resistance (AMR). The stark analysis covering more than 200 countries and territories was published in the Lancet. It says AMR is killing more people than HIV/Aids or malaria. Many hundreds of thousands of deaths are occurring due to common, previously treatable infections, the study says, because bacteria that cause them have become resistant to treatment. “These new data reveal the true scale of antimicrobial resistance worldwide, and are a clear signal that we must act now to combat the threat,” said the report’s co-author Prof Chris Murray, of the Institute for Health Metrics and Evaluation at the University of Washington. “We need to leverage this data to course-correct action and drive innovation if we want to stay ahead in the race against antimicrobial resistance.” Read full story Source: The Guardian, 20 January 2022
  13. News Article
    A new state of the art institute for antimicrobial research is to open at Oxford University thanks to a £100 million donation from Ineos. Ineos, one of the world’s largest manufacturing companies, and the University of Oxford are launching a new world-leading institute to combat the growing global issue of antimicrobial resistance (AMR), which currently causes an estimated 1.5 million excess deaths each year- and could cause over 10m deaths per year by 2050. Predicted to also create a global economic toll of $100 trillion by mid-century, it is arguably the greatest economic and healthcare challenge facing the world post-Covid. It is bacterial resistance, caused by overuse and misuse of antibiotics, which arguably poses the broadest threat to global populations. The world is fast running out of effective antibiotics as bacteria evolve to develop resistance to our taken-for-granted treatments. Without urgent collaborative action to prevent common microbes becoming multi-drug resistant (commonly known as ‘superbugs’), we could return to a world where taken-for-granted treatments such as chemotherapy and hip replacements could become too risky, childbirth becomes extremely dangerous, and even a basic scratch could kill. The rapid progression of antibacterial resistance is a natural process, exacerbated by significant overuse and misuse of antibiotics not only in human populations but especially in agriculture. Meanwhile, the field of new drug discovery has attracted insufficient scientific interest and funding in recent decades meaning no new antibiotics have been successfully developed since the 1980s. Alongside its drug discovery work, the IOI intends to partner with other global leaders in the field of Antimicrobial Resistance (AMR) to raise awareness and promote responsible use of antimicrobial drugs. The academic team will contribute to research on the type and extent of drug resistant microbes across the world, and critically, will seek to attract and train the brightest minds in science to tackle this ‘silent pandemic’. Read full story Source: University of Oxford, 19 January 2021
  14. Content Article
    In this article, Dr Diane Ashiru-Oredope and Eleanor Harvey from the UK Health Security Agency identify the risks of prescribing and dispensing oral antimicrobials and consider how pharmacy teams can minimise antimicrobial resistance.
  15. Content Article
    Antimicrobial resistance (AMR) is a major challenge to the UK’s health security, and is already responsible for a significant burden of death, disability and prolonged illness globally. The growing resistance of bacteria, viruses and fungi to the drugs commonly used to treat them threatens modern medicine, and our ability to carry out standard medical procedures. This report draws on the expert input of a roundtable held by public service think tank Reform in October 2022, to assess progress made against proposals published by Reform in 2020.
  16. Content Article
    This poster highlights some key issues associated with by antimicrobial resistance (AMR), which is caused by inappropriate use of antibiotics. It outlines the objectives and results of the AMR Patient Group, a coalition of patient groups across Europe working to address the serious public health threat posed by AMR. It also outlines the AMR Patient Group's policy recommendations to European and national health authorities.
  17. Content Article
    NHS England and Improvement, in collaboration with the National Institute for Health and Care Excellence (NICE) and the Department of Health and Social Care (DHSC), has selected the first antimicrobial drugs to be purchased via the UK’s innovative ‘subscription-type’ payment model. Antimicrobial resistance (AMR) refers to the process by which microorganisms develop defences against antimicrobial drugs, enabling these microorganisms to adapt and become resistant to treatment. It’s a serious problem and has recently been identified as one of the World Health Organization’s top 13 global health challenges in the next decade. Without working antibiotics, routine surgery like caesarean sections or hip replacements will become too dangerous to perform, cancer chemotherapy will become prohibitively high-risk and certain infections will require long and complex treatment; or will no longer be treatable. Already, the microorganisms that cause many common diseases around the world – including tuberculosis, malaria, gonorrhoea, urinary tract infections and chest infections – can resist a wide range of antimicrobial medicines. Like all global challenges, leaders in the international community need to come forward and act on AMR, and the UK – with the NHS as the world’s largest single public health system – is taking the initiative. NHS England and Improvement project leads, Mark Perkins and David Glover, discuss this important step in tackling AMR.
  18. Content Article
    Antibiotics are key to modern medicine and treatment. Many procedures and treatments developed over recent years, such as chemotherapy, organ transplants and other major surgery, rely on antibiotics to prevent infections. They are also crucial in treating some forms of pneumonia and other illnesses. However, an increasing number of common infections are becoming resistant to the drugs designed to treat them. This is called antimicrobial resistance (AMR). Antimicrobial stewardship (AMS) is part of the fight against AMR. The purpose of AMS is to ensure ‘the right antibiotic for the right patient, at the right time, with the right dose, and the right route, causing the least harm to the patient and future patients’. AMS programmes might include improving prescribing of antibiotics, promoting data collection and raising public awareness of AMR.
  19. Content Article
    I have worked in the UK NHS as a hospital pharmacist for 13 years, experiencing a variety of specialities before specialising in cancer and education and, more recently, gastroenterology.  I am also an avid traveller and have witnessed that, while we are globally connected, populations around the world are not as fortunate as we are in the UK for medicine and healthcare access and as a result are dying of very treatable diseases. This fuelled me to enrol on the Global Health Policy post-graduate masters (MSc). On completing my MSc, an opportunity arose to take part in the Global Health Fellowship and so I began working with Zambian colleagues at the University Teaching Hospital (UTH) and University of Zambia (UNZA), Lusaka, via the Brighton-Lusaka health link. This fellowship is a collaborative project between Commonwealth Pharmacists Association (CPA), Tropical Health and Education Trust (THET) and the Fleming Fund and is an avenue for pharmacists to become more involved in global health and improve medicine usage.
  20. Content Article
    Antibiotic resistance is increasing worldwide due to overuse and misuse of antibiotics. Newborn baby Amala has a life-threatening infection called septicemia. Will her antibiotic treatment work?  This video from the World Health Organization (WHO) explains what people can do to prevent the spread of antibiotic resistance.
  21. Content Article
    Antibiotic resistance is an increasingly serious threat to global health and human development. It is rising to dangerously high levels in all parts of the world, compromising our ability to treat infectious diseases and putting people everywhere at risk.
  22. Content Article
    Antimicrobial resistance leads to increased morbidity, mortality and healthcare costs worldwide. In order to contain antimicrobial resistance, Antibiotic Stewardship Programs (ASP) have been developed to measure and improve the appropriateness of antimicrobial use. A common way to measure the appropriateness of antimicrobial use is by evaluating whether antimicrobials are prescribed according to local guidelines and if not available, to national or international guidelines.
  23. Content Article
    ECRI Institute's Top 10 Patient Safety Concerns for 2020 features new topics, with an emphasis on concerns that have the biggest potential impact on patient health across all care settings. However, the number one topic on this year's list is one revisited from 2019: missed and delayed diagnoses.
  24. Content Article
    The world is on the cusp of an ominous development: bacteria are building resistance to existing antibiotics faster than new antibiotics are entering the market. An ever-widening cavity is opening up. This 'antibiotic gap', as experts call this development, marks the beginning of a new era in medicine. For the first time in recent history, we have to come to terms with the fact that not all bacterial infections are treatable anymore - with implications for all areas of medicine, from surgery to oncology. The World Health Organization has been using the term "silent pandemic" since the fall of 2021 because, unlike Covid, antibiotic resistance is creeping into our society unnoticed - but it is shaking up our healthcare system just as overarchingly. Silent Pandemic shows how countries, scientists and private initiatives around the world are networking and forming alliances, and what strategies and measures they are using to counter the advance of antibiotic resistance.
  25. Content Article
    It is important that patients and their medical team work in partnership when making decisions about using antibiotics, whether that’s when a GP prescribes an antibiotic or if you’re in hospital and need antibiotics. The Patients Association has developed these resources to help patients make informed decisions about taking antibiotics. They were developed in partnership with patients, carers, healthcare professionals and Pfizer Ltd., who funded and supported the project. The information will help patients partner with their medical team when deciding about using antibiotics. These resources focus on when a patient is in the hospital, but they may also be used as a helpful reminder whenever you are considering taking antibiotics. The resources include a patient leaflet and animated video.
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