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Found 453 results
  1. Content Article
    The UK Covid-19 Inquiry has been set up to examine the UK’s response to and impact of the Covid-19 pandemic, and learn lessons for the future. The Inquiry’s work is guided by its Terms of Reference.
  2. News Article
    Scientists have "super-engineered" polio vaccines to prevent them mutating into a dangerous form that can cause outbreaks and paralysis. The oral vaccines contain weakened live polio viruses and the genetic redesign locks them into that weakened state. The US and UK teams have now created upgraded vaccines against all three types of polio. However, better vaccines still need to reach every child in order to stop the disease. Read full story Source: BBC News, 14 June 2023
  3. Content Article
    The National Vascular Registry (NVR) has published a report on the impact of the Covid-19 pandemic on vascular surgery in the UK, presenting key findings from NVR data throughout 2020 and 2021. NVR previously reported on data as at 25 September 2020, which showed that Covid-19 infection in patients undergoing vascular surgical procedures significantly increased the risk of respiratory complications and mortality. Here, they update this analysis, using data through to the end of 2021, and explore whether the Covid-19 vaccination programme provided protection to patients against this life-threatening complication. One finding is that, between March 2020 and Dec 2021, confirmed postoperative Covid-19 diagnoses were most common among non-elective procedures, ranging from 18.4% (non-elective AAA repair) to 27.5% (major lower limb amputation). For elective procedures, the reported rates of confirmed postoperative Covid-19 diagnoses were lower, ranging from 1.6% (elective AAA repair) to 4.1% (lower-limb bypass). Other key findings include: There was only a modest rise during the first Covid-19 wave (Mar-Jun 2020) with a larger rise during the second wave (Nov 2020-Feb 2021) There was a different pattern for respiratory complications after surgery, with higher rates observed in both wave 1 and wave 2 The period from March to December 2021 was associated with rates of respiratory complications and in-hospital postoperative mortality returning to levels observed pre-pandemic in 2019 Overall, the report concludes that the vaccination programme had a modest benefit to patients in reducing the risk of respiratory complications, and therefore carries a public health message relevant for both national and international audiences.
  4. Content Article
    Pharmacovigilance is the observation and monitoring of possible harms from exposure to a variety of pharmaceuticals, biologics and devices. In this blog, Professor of Evidence-based Medicine Carl Heneghan and Clinical Epidemiologist Tom Jefferson talk about a recent attempt to obtain data on the incidence of deaths following Covid-19 vaccination from the Medicines & Healthcare Products Regulatory Agency (MHRA) through a Freedom of Information request. They describe how the MHRA initially said they were unable to provide the information as it would cost too much to extract, and after sending a follow up request to the MHRA's Chief Safety Officer, they have not heard anything further after an initial promise to investigate. They argue that the MHRA is failing the public by failing to investigate the side effects of Covid vaccines using information from Yellow Card reports. This blog is paywalled once you have read a certain number of articles each month.
  5. News Article
    A group of doctors, including some GPs, has begun legal proceedings against the GMC based on what they say is a failure to act on Covid-19 vaccine misinformation. On Friday, the group, whose members wish to remain anonymous, sent a formal pre-action protocol letter to the GMC, which is a warning that legal action is imminent. In January, these doctors called on the regulator to investigate Dr Aseem Malhotra’s fitness to practise due to what they claim is his ‘high-profile promotion of misinformation about Covid-19 mRNA vaccines’. Dr Malhotra, a consultant cardiologist, campaigner and author, has over half a million followers on Twitter, with most recent posts focusing on the Covid vaccine. The upcoming action, which is led by lawyers from the Good Law Project, is based on the GMC’s refusal to carry out an investigation. Professor Trish Greenhalgh, a GP and academic in primary care at the University of Oxford who has been in touch with the group, told Pulse the ‘scandal is that the GMC do not think it’s their job to investigate doctors who have massive, massive followings on social media and who fan the flames of disinformation’. Read full story Source: Pulse, 5 June 2023
  6. Content Article
    In February 2023, the government commissioned an independent review to offer recommendations on how to resolve key challenges in conducting commercial clinical trials in the UK and transform the UK commercial clinical trial environment. The review sets out 27 recommendations, including both priority actions to progress in 2023 and longer-term ambitions for UK commercial clinical trials. The review was conducted by Lord James O’Shaughnessy, Senior Partner at consultancy firm Newmarket Strategy, Board Member of Health Data Research UK (HDR UK) and former Health Minister, who was appointed as review Chair. During the review, Lord O’Shaughnessy consulted closely with industry and a wide range of stakeholders across the UK clinical trials sector. The government response welcomes all recommendations from the review, in principle, and makes 5 headline commitments backed by £121 million. An implementation update, setting out progress made against these commitments and a comprehensive response to the remaining recommendations, will be published in the autumn.
  7. Content Article
    In this letter to The Lancet, Thomas Cueni, Director General of the International Federation of Pharmaceutical Manufacturers and Associations argues that the need to focus on equitable rollout of vaccines in the event of a future pandemic is a key global health priority. He proposes that Governments, pharma companies and other stakeholders should focus on the challenges that led to the inequitable rollout of vaccines, which he identifies as vaccine nationalism and need for more diverse manufacturing. He highlights an industry proposal for equitable response to future pandemics supported by vaccine manufacturers and biotechnologies. the proposal involves manufacturers setting aside a percentage of pandemic tools for allocation to susceptible populations in low-income countries.
  8. Content Article
    The Covid-19 pandemic has shown the power and potential of vaccination in real time. But it has also disrupted health services and caused supply chain challenges, resulting in stagnation and backsliding of routine vaccinations. For example, global coverage of the third dose of the diphtheria–tetanus–pertussis vaccine fell from 86% in 2019 to 81% in 2021—the lowest level since 2008. 25 million children missed out on life-saving measles, diphtheria, and tetanus vaccines in 2021. This editorial in The Lancet calls for a catch-up to return to pre-pandemic vaccination levels and looks at how this can be achieved.
  9. News Article
    A "very concerning" rise in the number of people catching measles in the UK has been reported by health officials. There were 54 cases of measles in the whole of last year. However, there have already been 49 in the first four months of 2023. The UK Health Security Agency (UKHSA) is encouraging parents to ensure their children's vaccinations are up to date. The main symptoms of measles are a fever and a rash. But it can cause more serious complications including meningitis, and an infection can be fatal. Vaccination rates had been falling in the UK before the Covid pandemic. However, the disruption caused by Covid has dented vaccination programmes around the world, including in the UK, meaning even more children have missed out. The World Health Organization has already warned of a "perfect storm" for measles, because the fewer people who receive protection from vaccines, the easier it is for outbreaks to happen. Read full story Source: BBC News, 4 May 2023
  10. News Article
    The US Food and Drug Administration has approved a vaccine against respiratory syncytial virus (RSV) - an illness that kills thousands of Americans each year. The vaccine still needs approval from the US Centers for Disease Control and Prevention before it can be rolled out to the public. Officials say the vaccine, named Arexvy by the manufacturer GSK, is a major breakthrough that will save many lives. It could be available to people over 60 within months, officials say. "Today's approval of the first RSV vaccine is an important public health achievement to prevent a disease which can be life-threatening," said Dr Peter Marks, who leads the Center for Biologics Evaluation and Research at the Food and Drug Administration (FDA). RSV is a respiratory illness that typically results in cold-like symptoms for adults, but can be dangerous for young children, the elderly, and those with underlying health conditions. Read full story Source: BBC News, 4 May 2023
  11. Content Article
    At Patient Safety Learning we believe that sharing insights and learning is vital to improving outcomes and reducing harm. That's why we created the hub; providing a space for people to come together and share their experiences, resources and good practice examples.  This week is World Immunisation Week so our Content and Engagement Manager, Lotty, has picked nine resources full of practical advice about vaccination in a range of settings.
  12. News Article
    More teenagers are at risk of contracting rare but serious diseases due to a fall in immunisations as a result of the pandemic, according to a report. The uptake of vaccines among teenagers in secondary schools that protect against meningococcal disease, diphtheria, tetanus and polio has dropped since COVID affected routine school immunisation programmes provided by the NHS. The UK Health Security Agency (UKHSA) found that 69% of children in year nine, aged 13 and 14, had the MenACWY vaccine and the Td/IPV booster in 2021-22. This marked a 7% drop in coverage for both vaccines compared to the previous year. The 3-in-1 Td/IPV booster helps provide teens with long-lasting protection against tetanus, diphtheria and polio, diseases that can result in serious illness or even death. Doctor Vanessa Saliba, consultant epidemiologist at UKHSA said: "In recent years we have seen vaccine uptake fall due to the challenges posed by the pandemic. "Many young people who missed out on their vaccinations have already been caught up, but more needs to be done to ensure all those eligible are vaccinated. "These vaccines offer the best protection as young people start their journey into adulthood and mixing more widely - whether going to college, starting work, travelling or going to summer festivals." Read full story Source: Sky News, 24 April 2023
  13. News Article
    A father whose baby died at six weeks after his vitamin K jab was missed has urged parents not to be taken in by misinformation spreading across social media. Alex Patto, 33, and his wife wanted their newborn son, William, to have the vitamin K jab to protect him against a rare but serious bleeding disorder known as vitamin K deficiency bleeding (VKDB). But the Rosie Hospital in Cambridge missed the jab and their firstborn child tragically passed away at six weeks old after suffering a bleed on his brain. Cambridge University Hospitals NHS Foundation Trust has completed a serious incident report and an inquest is due to take place in the coming months. Having gone through baby loss, Alex said he finds it “hard to understand” why parents would trust unverified information on social media over advice from their healthcare professional to opt into the jab. iNews previously revealed an increase in anti-vaccination misinformation on social media discouraging parents from getting the vitamin K jab for their newborn babies. The jab is a vitamin injection, not a vaccine – which are given to protect against infectious diseases – but doctors have reported videos on social media are incorrectly mislabelling it as such. Read full story Source: iNews, 23 March 2023
  14. News Article
    Ghana is the first country to approve a new malaria vaccine that has been described as a "world-changer" by the scientists who developed it. The vaccine - called R21 - appears to be hugely effective, in stark contrast to previous ventures in the same field. Ghana's drug regulators have assessed the final trial data on the vaccine's safety and effectiveness, which is not yet public, and have decided to use it. The World Health Organization is also considering approving the vaccine. Malaria kills about 620,000 people each year, most of them young children. It has been a massive, century-long, scientific undertaking to develop a vaccine that protects the body from the malaria parasite. But widespread use of the vaccine hinges on the results of a larger trial involving nearly 5,000 children. These had been expected to take place at the end of last year, but have still not been formally published. However, they have been shared with some government bodies in Africa, and scientists. Read full story Source: BBC News, 13 April 2023
  15. Content Article
    There has been increasing public concern that COVID-19 vaccination causes menstrual disturbance regarding the relative effect of vaccination compared to SARS-CoV-2 infection. The objectives of this study, published in Science Direct, were to test potential risk factors for reporting menstrual cycle changes following COVID-19 vaccination and to compare menstrual parameters following COVID-19 vaccination and COVID-19 disease.
  16. News Article
    Federal regulators have decided to authorise a second omicron-specific coronavirus vaccine booster shot for people who are at least 65 or have weak immune systems in an effort to provide additional protection to high-risk individuals, according to several officials familiar with the plan. The Food and Drug Administration is expected to announce the step in the next few weeks, and the Centers for Disease Control and Prevention is expected to move quickly to endorse it, said the officials, who spoke on the condition of anonymity because they were not authorised to publicly discuss internal discussions. Eligible individuals will be able to receive the dose as long as it has been at least four months since their first shot of what’s known as the bivalent booster, which targets omicron subvariants BA.4 and BA.5 as well as the original novel coronavirus. The expectation is that consumers will consult with their health-care providers about whether to get the extra booster, the officials said. John P. Moore, a professor of microbiology and immunology at Weill Cornell Medicine in New York, said an extra booster could benefit people who are in poor health or have an impaired immune system. But he was skeptical everyone older than 65 needs it. Boosters lead to “a short-term boost against mild infection but protection against severe disease is still pretty robust” because of previous shots, he said. Read full story (paywalled) Source: Washington Post, 3 April 2023
  17. Content Article
    In this study, Tsampasian et al. looked at what the risk factors were for developing post−COVID-19 condition (also known as Long Covid). The systematic review and meta-analysis of 41 studies, including 860 783 patients, found that female sex, older age, higher body mass index, smoking, preexisting comorbidities, and previous hospitalisation or ICU admission were risk factors significantly associated with developing Long Covid, and that SARS-CoV-2 vaccination with two doses was associated with lower risk of Long Covid. The findings of this systematic review and meta-analysis provide a profile of the characteristics associated with increased risk of developing Long Covid and suggest that vaccination may be protective against Long Covid.
  18. News Article
    London primary-school pupils not fully vaccinated against polio are to be offered catch-up jabs after Easter. The disease, common in the UK in the 1950s, was eliminated by 2003. But poliovirus traces were found in north and east London sewage in early 2022. An emergency vaccination-booster campaign in London last summer reached more than 370,000 children. And in early November, the latest tests found less of the virus - but officials say there is no room for complacency. Dr Vanessa Saliba, from the UK Heath Security Agency, told BBC News: "We have early signs that there's less spread of poliovirus in London - but we will need 12 months of no detections before the World Health Organization could declare that the UK is no longer an infected country." Polio causes paralysis in a very small number of cases where the virus attacks the nerves in the spine and base of the brain - but most are asymptomatic. Read full story Source: BBC News, 23 March 2023
  19. Content Article
    In this blog, TranspariMED Founder Till Bruckner reviews The Truth Pill: The Myth of Drug Regulation in India, a new book that looks at problems with the medications regulatory system in India. The book's authors, Dinesh S. Thakur and Prashant Reddy T, draw on in-depth legal and regulatory analyses, numerous case studies and responses to hundreds of Freedom of Information requests to document glaring gaps in India’s legal framework and severe shortcomings in regulatory oversight and enforcement.
  20. Content Article
    Co-produced by young people and researchers from the University of Bristol and London School of Hygiene and Tropical Medicine, ‘EDUCATE’ will help teach students about the human papillomavirus (HPV) vaccine and provide reassurance about receiving the vaccine, which is usually offered to teenagers at school as part of the national vaccination programme.
  21. News Article
    Plans to prevent one of the deadliest cancers for women in Jamaica have been significantly set back by the Covid pandemic, new figures reveal. The scheme to vaccinate schoolgirls against cervical cancer in Jamaica – which is the cancer with the second highest death rate in the Americas – began in 2018, but the Pan American Health Organization says inoculation rates fell to just 2.71% in 2021. This represents a drastic drop from the 2019 rate of 32%, and far from the WHO target of 90% by 2030. The cancer, which is curable if caught early, kills 22 in every 100,000 women in Jamaica. By comparison, in the UK the rate is 2.4 in every 100,000, and in Canada it is 2. Prevention of cervical cancer in Jamaica is also hindered by low rates of cervical screenings. “Women are afraid of the screening process and potential pain, but there is also a fear of a cancer diagnosis itself,” said Nicola Skyers of Jamaica’s Ministry of Health. “Some people just prefer not to know. But I also think that healthcare providers don’t offer screenings often enough. If a healthcare provider is really ‘selling’ the pap smear, more often than not the woman will choose to have it.” Health workers are forced to focus on cures rather than preventions amid staffing shortages and an overburdened healthcare system, said Skyers. “As a doctor, you won’t be encouraging every women you see to do a pap smear if you have 40 patients waiting outside.” Read full story Source: The Guardian, 2 February 2023
  22. Content Article
    In this report, Dr Henrietta Hughes, Patient Safety Commissioner for England, reflects on her first 100 days in this new role. She sets out what she has heard, what she has done and her priorities for the year ahead.
  23. News Article
    Hepatitis B transmission from mothers to babies has been eliminated in England, according to the World Health Organisation (WHO). The WHO elimination target is that less than 2% of babies born to mothers with hepatitis B go on to develop the infection. And data from the UK Health Security Agency (UKHSA) shows the figure for England currently stands at 0.1% The UKHSA said progress had been made in tackling the viral infection, which can cause liver damage, cancer and death if left untreated. A six-in-one vaccine is offered to all babies on the NHS when they are eight, 12 and 16 weeks of age. Health and Social Care Secretary Steve Barclay said: “We are paving the way for the elimination of hepatitis B and C, with England set to be one of the first countries in the world to wipe out these viruses.” Read full story Source: The Independent, 2 February 2023 .
  24. Content Article
    The average life expectancy for people with a learning disability is significantly lower than for the general population. Sadly, many of these premature deaths are avoidable.  Mandy Anderton is a Clinical Nurse specialising in learning disability. In this interview she explains some of the barriers people with a learning disability face in accessing safe care and how adjustments can be made within GP practices to improve outcomes.  Mandy ends with a list of national improvements that she believes would reduce health inequalities in this area. 
  25. News Article
    The BBC has come under fire from scientists for interviewing a cardiologist who claimed certain Covid vaccines could be behind excess deaths from coronary artery disease. Experts have criticised Dr Aseem Malhotra’s appearance on the BBC's news channel last Friday, accusing him of pushing “extreme fringe” views, which are “misguided”, “dangerous” and could mislead the public. Scientists have described the doctor as “hijacking” an interview on statins to air his views, causing BBC staff to be “alarmed and embarrassed” by their booking. Malhotra recently retweeted a video by the MP Andrew Bridgen, who had the Tory whip removed on Wednesday after comparing the use of Covid vaccines to the Holocaust. After criticising new guidance on statins, he cited British Heart Foundation (BHF) figures that suggested there had been more than 30,000 excess deaths linked to heart disease since Covid first arrived. Malhotra, a cardiologist at ROC Private Clinic, claimed mRNA Covid vaccines play a role, saying his “own research” showed “Covid mRNA vaccines do carry a cardiovascular risk”. He added that he has called for the vaccine rollout to be suspended pending an inquiry because of the “uncertainty” behind excess deaths. Read full story Source: The Guardian, 13 January 2023
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