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Found 1,136 results
  1. Content Article
    Pharmaswiss Česka republika s.r.o. and distributor Bausch & Lomb UK Limited is recalling all unexpired batches of Emerade 500 micrograms and Emerade 300 micrograms adrenaline auto-injectors (also referred to as pens) from patients. This is due to an issue identified during an ISO 11608 Design Assessment study where some auto-injectors failed to deliver the product or activated prematurely. Specifically, the 1-metre free-fall (vertical orientation) pre-conditioning resulted in damage to internal components of the auto-injector, leading either to failure to deliver the product or premature activation. This damage was not visibly apparent following the pre-conditioning but was evident only on subsequent functional testing. It is unclear what impact this has on auto-injectors in clinical use, however as a precautionary measure and owing to the inability to identify this issue before the auto-injectors are used, the auto-injectors are being recalled. Healthcare professionals should inform patients, or carers of patients, who carry Emerade 300 or 500 microgram auto-injector pens to obtain a prescription for and be supplied with an alternative brand. They should then be informed to return their Emerade 300 or 500 microgram pens to their local pharmacy.
  2. Content Article
    This recent cohort study, published in Evidence Based Medicine, investigated ‘the risk of transitioning from acute to prolonged use’ of opioid analgesics in patients undergoing elective surgery. Patients given tramadol or long-acting opioids after discharge were at greater risk of prolonged opioid use than those who were given other short-acting opioids.
  3. Content Article
    The opioid crisis in the United States (US) is one of the most high-profile public health scandals of the 21st century with millions of people unknowingly becoming dependent on opioids. The United Kingdom (UK) had the world’s highest rate of opioid consumption in 2019, and opiate-related drug poisoning deaths have increased by 388% since 1993 in England and Wales. This article, published in the British Journal of Pain, explores the epidemiological definitions of public health emergencies and epidemics in the context of opioid use, misuse, and mortality in England, to establish whether England is facing an opioid crisis.
  4. Content Article
    Many AI models are being developed and applied to understand opioid use. However, authors of this paper, published in BMJ Innovations, found there is a need for these AI technologies to be externally validated and robustly evaluated to determine whether they can improve the use and safety of opioids.
  5. Content Article
    Coroners inquire into sudden, unexpected, or unnatural deaths. We have previously established 99 cases (100 deaths) in England and Wales in which medicines or part of the medication process or both were mentioned in coroners’ ‘Regulation 28 Reports to Prevent Future Deaths’ (coroners’ reports). Authors of this paper, published in Drug Safety, aimed to see what responses were made by National Health Service (NHS) organisations and others to these 99 coroners’ reports.
  6. Content Article
    Deaths from opioids have increased in England and Wales, despite recognition of their harms. Coroners’ Prevention of Future Death reports (PFDs) provide important insights that may enable safer use and avert harms, yet these reports involving opioids have not been synthesised. Authors of this commentary, published in the Journal of the Royal Society of Medicine, therefore aimed to identify opioid-related PFDs and explore concerns expressed by coroners to prevent future deaths.
  7. Content Article
    Medicines cause over 1700 preventable deaths annually in England. Coroners’ Prevention of Future Death reports (PFDs) are produced in response to preventable deaths to facilitate change. The information in PFDs may help reduce medicine-related preventable deaths. Authors of this paper, published in Drug Safety, aimed to identify medicine-related deaths in coroners’ reports and to explore concerns to prevent future deaths.
  8. Content Article
    Guidance needs to be applied in a careful, caring and person-centred way to ensure that patients benefit from, and are not harmed by, healthcare. In this blog, Dr Sam Finnikin, an academic GP in Sutton Coldfield, uses the story of 86 year-old Joan to illustrate the importance of shared decision-making in ensuring patients receive the most appropriate care. Joan was prescribed multiple medications by the hospital cardiology team after being diagnosed with acute coronary syndrome and a severely impaired left ventricle, but the medications made her feel very unwell and inhibited her quality of life. Joan then reached out to her GP surgery as she wanted to stop taking them, and Dr Finnikin realised that she and her family were unaware of the the reason each medication had been prescribed and the potential benefits and side effects of each one. After a long conversation about her priorities, Joan stopped the medications that were not benefitting her symptoms and died in peace and comfort at home a few weeks later. Dr Finnikin argues that shared decision-making is not an optional extra, but must be considered a vital part of healthcare, stating that "omitting shared decision making can be just as harmful to patients as being ignorant of clinical recommendations."
  9. Gallery Image
    Fentanyl and naloxone.jpg
    Fentanyl, a synthetic opioid, and naloxone, a medication used to reverse or reduce the effects of opioids, both in very similar bottles and packaging. Shared originally on Twitter by @sassistheword
  10. Gallery Image
    Noradrenaline and tranexamic acid.jpg
    Shared with hub by Dr Abigail Clark-Morgan: Images shared of our stocked noradrenaline ampules and tranexamic acid – these have been mixed up and we are looking to stock alternative volumes of noradrenaline to reduce the likelihood of confusion. The incident also highlighted the importance of checking all the ampules drawn up, drawing up your own medications at the point of administration and effective second checking. Part of our immediate response was to label the noradrenaline ampules to make them more obviously different (the purple ampules pictured below).

    © Healthcare UK

  11. Gallery Image
    Midazolam.jpg
    Shared from Twitter: What could go wrong? Same size, same colourings … Time for distinct and standardised size/colouring of paralytic agents?
  12. Gallery Image
    Bupivacaine and sodium chloride
    Do we need a magnifying glass in every anaesthetic room? Only a matter of time until something bad happens...
  13. Gallery Image
    Sodium chloride and levobupivacaine
    Levobupivacaine is a local anaesthetic. Labelling very similar to the Sodium chloride.
  14. Gallery Image
    Glyco ampoules.jpg
    Can you read this glyco ampoule? Very small writing on the label - difficult to read, especially when in a hurry.
  15. Gallery Image
    Solutions for injections
    Three very different solutions for injection - magnesium sulfate, water, sodium chloride - so why is the labelling so similar?
  16. Gallery Image
    Clobazam.jpg
  17. Gallery Image
    Sodium Cholride and Metronidazole.jpg
  18. Gallery Image
    Which drug is which?
    Ondansetron, metoclopramide and oxytocin. Which is which? Very different drugs but very similar bottles and labels.
  19. Gallery Image
    Sodium Chloride and paracetamol solution.jpg
    These two solutions look very similar. One is paracetamol, the other Sodium Chloride. Example of packaging/labelling contributing to adverse events.
  20. Gallery Image
    Aspirin.jpg
    A patient bought wrong aspirin from pharmacy and accidentally overdosed. Easily done with such similar packaging.
  21. Gallery Image
    Rocuronium bromide and Midazolam
    Why would manufacturers make labelling for rocuronium orange? This is something you wouldn't want to muddle up.
  22. Gallery Image
    Heparinised saline and lignocaine.jpg
  23. Gallery Image
    Calcium Gluconate and Sodium Chloride solutions.jpg
  24. Gallery Image
    Medication - generic names.png
  25. Gallery Image
    TEARDEW (COMPILED).png
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