Reducing hospitalizations and multidrug-resistant organisms via regional decolonisation in hospitals and nursing homes (1 April 2024)

Summary

Infections due to multidrug-resistant organisms (MDROs) are associated with increased morbidity, mortality, length of hospitalisation, and health care costs. Regional interventions may be advantageous in mitigating MDROs and associated infections.

This study evaluated whether implementation of a decolonisation collaborative is associated with reduced regional MDRO prevalence, incident clinical cultures, infection-related hospitalisations, costs, and deaths.

It found a regional collaborative involving universal decolonisation in long-term care facilities and targeted decolonisation among hospital patients in contact precautions was associated with lower MDRO carriage, infections, hospitalisations, costs, and deaths.