Estimating the economic effect of harm associated with high risk prescribing of oral non-steroidal anti-inflammatory drugs in England: population based cohort and economic modelling study (24 July 2024)

Summary

This BMJ cohort study aimed to quantify the prevalence, harms and NHS costs in England of problematic oral non-steroidal anti-inflammatory drug (NSAID) prescribing in high risk groups. It found that NSAIDs continue to be a source of avoidable harm and healthcare cost in five high risk populations—older adults with no gastroprotection, people who concurrently took oral anticoagulants, people with heart failure, those with chronic kidney disease and those with a history of peptic ulcer. Harm was common in people with chronic conditions and people taking oral anticoagulants.