Stewardship prompts to improve antibiotic selection for pneumonia: The INSPIRE randomized clinical trial (19 April 2024)

Summary

Computerised provider order entry (CPOE) prompts can provide patient-specific risk estimates for multidrug-resistant organisms (MDROs). This JAMA Network study aimed to find out whether CPOE prompts could reduce empiric extended-spectrum antibiotic use in patients admitted with pneumonia. The authors found that prompts promoting standard-spectrum antibiotics for patients at low risk of infection with MDROs reduced extended-spectrum antibiotic use by 28.4%, without increasing intensive care unit transfers or length of stay for patients with pneumonia.