SARS-CoV-2 infection can damage many organs other than the lungs. The most troubling is damage to the brain. A series of recent studies document long term brain-damage in as many as one quarter of all those infected regardless of the severity of the initial disease. Those numbers are daunting considering that an estimated 140 million Americans have been infected by SARS-CoV-2. Symptoms, such as brain fog, fatigue, depression and a host of other maladies, may be mild or incapacitating. Several studies warn that treatment of those with long term brain injury will strain the healthcare care system for years to come. Understanding the origin and treatment of Covid-19 related brain injury is a high priority for medical science.