Experts warn GPs on prescribing antipsychotic drugs for dementia

Doctors are being urged to reduce prescribing of antipsychotic drugs to dementia patients after the largest study of its kind found they were linked to more harmful side-effects than previously thought.

The powerful medications are widely prescribed for behavioural and psychological symptoms of dementia such as apathy, depression, aggression, anxiety, irritability, delirium and psychosis. Tens of thousands of dementia patients in England are prescribed them every year.

Safety concerns have previously been raised about the drugs, with warnings to medics based on increased risks for stroke and death, but evidence of other dangers was less conclusive.

New research suggests there are a considerably wider range of harms associated with their use than previously acknowledged in regulatory alerts, underscoring the need for increased caution in the early stages of treatment.

Antipsychotic use in dementia patients was associated with elevated risks of a wide range of serious adverse outcomes, including stroke, blood clots, heart attack, heart failure, fracture, pneumonia and acute kidney injury, the study’s authors reported. 

Read full story

Source: The Guardian, 18 April 2024