Some healthcare practices, including tasks intended to make care safer, are implemented without any evidence that they are of benefit, and can add an unnecessary burden to the day-to-day work of healthcare staff. This six-step toolkit provides resources to help identify which tasks or processes might be suitable for streamlining, and a step-by-step a guide to developing an evidence-based strategy for safely rethinking, reducing or removing a practice. It has been developed by the Yorkshire Quality and Safety Research Group at the Bradford Institute for Health Research, UK, through consultation with healthcare professionals and public contributors.