Alternative to prophylactic antibiotics for the treatment of recurrent urinary tract infections in women: multicentre, open label, randomised, non-inferiority trial (9 March 2022)

Summary

Antibiotic resistance is a growing issue for medicine globally, so finding alternative medications is a priority for medical research. This study in The BMJ aimed to test and compare the efficacy of methenamine hippurate with the current standard use of daily low dose antibiotics to prevent recurrent urinary tract infections in women.

The authors of the study concluded that non-antibiotic prophylactic treatment with methenamine hippurate might be appropriate for women with a history of recurrent episodes of urinary tract infections. The study demonstrated that the treatment had a similar success rate as daily antibiotic prophylaxis.