Adverse drug events caused by three high-risk drug–drug interactions in patients admitted to intensive care units: A multicentre retrospective observational study (11 August 2023)

Summary

Knowledge about adverse drug events caused by drug–drug interactions (DDI-ADEs) is limited. Authors of this study aimed to provide detailed insights about DDI-ADEs related to three frequent, high-risk potential DDIs (pDDIs) in the critical care setting: pDDIs with international normalised ratio increase (INR+) potential, pDDIs with acute kidney injury (AKI) potential, and pDDIs with QTc prolongation potential.

They found that the highly preventable nature and severity of DDI-ADEs, calls for action to optimize ICU patient safety. Use of e-triggers proved to be a promising preselection strategy.